PREFACE: Hello, I'm the archetypical hybrid
(HEC)
I'm a student majoring in neuropharmacology, organic chemistry, chemical &
mechanical engineering, and I'm conducting some private research on phenomenal pheromones as described
hereafter.
For your referances:
androsta-4,16-dien-3-one =
androstadienone
5α-androstan-3-one =
androstAnone
5α-androst-16-en-3-one = androstenone
4-androsten-3-one
= 4-androstenone
Based upon the quantitative structure-property relationships I've studied for
steroids which are active at the human female VNO, I believe that 4-ANDROSTEN-3-ONE (DESOXYTESTOSTERONE), may be
very active at the human female VNO. This hypothesis is derived from the fact that only two pheromones:
androsta-4,16-dien-3-one, and 5α-androstan-3-one are significantly active at the human female
VNO [as substantiated by an Erox study long ago titled: the sixth sense].
5α-androstan-3-one is a saturated analogue of 5α-androst-16-en-3-one (a pig
pheromone), which has an alkene group at the 16th carbon of the prototypical skeletal molecule.
5α-androst-16-en-3-one does not target the human female VNO, whereas
5α-androstan-3-one does; the only difference being the alkene group at the 16th carbon. Now,
androsta-4,16-dien-3-one, an analogue of 5α-androst-16-en-3-one is very active at the human
female VNO, the only difference between the two being an alkene group at the 4th carbon.
From logical deduction and
quantitative structure-property relationships, I assert the following:
A) An alkene group at the 3rd carbon of
the skeletal molecule dramatically increases activity at the VNO
B) A fully saturated group at the 16th-17th
carbons also significantly increases activity.
EPILOGUE: Therefore, it is my hypothesis that
4-androsten-3-one, as a molecular hybrid containing the most desired substitutions may be very active at the human
female VNO, more so than the archetypical androsta-4,16-dien-3-one. If possible I ask for you good folks within this
esoteric paradigm to voice your opinion with respect to this hypothesis.
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