Qrius,
For SOE I really wouldn\'t worry to much about ODing. I typicall use about 12\" total rolled on my arms, neck, and behind the ears.
As for RM two drops for me required about at least an hour of wait to get interesting rxns. Haven\'t tried NPA by itself, but 2 drops should be a good start. Another thing that you should also keep in mind that at these concentrations you should see rxns in enclosed spaces (including 12\" of SOE). Outdoors tend to be much harder to get hits. You have to be closer to the target since this stuff disapates really well outdoors.
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