Androstanone?

[Andras]

Anybody been playing

around with the androstanone in their chem sets? I have a really big feeling that it acts just like -none but much

more potent. I've worn just -none before but i never had seen other people respond to the smallest amount of

androstanone before. It's potent enough to interfere with even simple tasks, real mindfuck. gonna end up going

right back to just -nol and -rone, all the -nones are just way to powerful for me.

[Archetypical Hybrid (HEC)]

AndrostAnone

was hypothesized to be more biologically active at the human female VNO versus androstenone, due to structure

activity relationship observations.

I do know that androstAnone is a component in - my analysis of the

mix did prove this much. Quantitative analysis not performed.

[bronzie]

AndrostAnone was hypothesized to be more biologically active at the human female VNO versus androstenone, due

to structure activitiy relationship observations.

VNO is a non functioning organ, therefore I

believe that the hypothsis you mentioned above is incorrect.

[Archetypical Hybrid (HEC)]

VNO is a

non functioning organ, therefore I believe that the hypothsis you mentioned above is incorrect

Au

Contraire! I'd like to see your evidence bronzi boy.. While the VNO is less of a driving force in higher

mammels (such as are we) it nontheless influences behavior - this is common knowledge.

There is also the fact

that physiological reaction (behavior) to a vomeropherin (such as in Androstadienone [or A1]) strongly correlates

its activity at the VNO. Same story with Estratetraenol.

AndrostAnone is known to evoke a

stronger response in the human female VNO then does androstenone (thus proving my original theory correct).

See

for yourself:


AndrostAnone is the first bar

shown (5α-androstan-3-one)


Androstenone (-none) is the

forth one listed (5α-androst-16-en-3-one)


Androstadienone is the fifth one listed

(androsta-4,16-en-3-one)



P.S. There is also

the fact that androstAnone is far more volatile than androstenone. AndrostAnone's MP is 103˚C,

whereas androstenone's MP is 145˚C (according to the Sigma-Aldrich catalog). Thus, the vapor

pressure is higher and hence it evaporates into the air (where pheromones are active) much moreso than

androstenone.

[Icehawk]

Anybody been

playing around with the androstanone in their chem sets? I have a really big feeling that it acts just like -none

but much more potent. I've worn just -none before but i never had seen other people respond to the smallest amount

of androstanone before. It's potent enough to interfere with even simple tasks, real mindfuck. gonna end up going

right back to just -nol and -rone, all the -nones are just way to powerful for me.

Describe the

potent part. Easier to OD? More widespread effects? More prominent smell? Made you kill someone? What?

[maxo-texas]

Hec,
I *love* your

picture.

What was the response invoked in your graph? Was it electrical, behavioral, physical?

[Icehawk]

It would actually

explain why none of the men got angry at me personally, it was more that just the women around me would notice that

there was a "stink", but most of them just ended up wetting themselves and then the guys around the girls would

notice that smell. truthfully, I'm not sure if the guys could just not smell the -stanone but i couldn't smell it,

i could just smell the pussy juice coming off the girls.

And you call that a bad thing?

Probably a good addition to any NPA like mix. More testing necessary it seems.

Hec,
I

*love* your picture.

What was the response invoked in your graph? Was it electrical, behavioral,

physical?

Its rated in EVG or Electrovomeronasogram. So yeah it was electrical.

[maxo-texas]

Cool.

That's hard

science. No opinion to that.

Given the extreme reaction to stenone by of of my gf, it makes me very curious to

see her reaction to stanone.

Currently testing beta-estreanone( sp)? on all of them so -stanone will ahve to wait

til jan.

[Icehawk]

Cool.



That's hard science. No opinion to that.

Given the extreme reaction to stenone by of of my gf, it

makes me very curious to see her reaction to stanone.

Currently testing beta-estreanone( sp)? on all of them

so -stanone will ahve to wait til jan.

Cool plz post your results so others can benefit

[Archetypical Hybrid (HEC)]

Hec,
I *love* your picture.

What was the response invoked in your graph? Was it electrical, behavioral,

physical?

As per Ice's observations, the response is in fact electrical. Basically, the protocol consists

of an in vitro testing environment, wherein a VNO organ is bathed in nutrients and the nerve connections are

affixed to an electrogram, which measures the strength of the electrical impulse from the VNO, while exposed to the

vapors of various different pheromones.

The bar graph shown there is from the Erox studies (they invented

androstadienone and estratetraenol). I do have some molecular concepts which follow the train of thought executed

with androstAnone (which proved to be true). I think a derivative of androstadienone exists which will demonstrate

much stronger responses than androstadienone. I have the resources at my local college campus to recreate the

original erox studies and measure the response from my theoretical pheromones, and compare them to the known

responses for androstadienone.

I was thinking even of maybe trying to start up a private research fund, to help

facilitate this research. Thoughts, comments on this??

[Mtnjim]

... (they invented androstadienone and estratetraenol).

I thought God/Mother Nature invented

them.

I was thinking even of maybe trying to start up a private research fund, to help facilitate

this research. Thoughts, comments on this??

So, are you a first year Biochemistry student or a post doc,

or what??

[Archetypical Hybrid (HEC)]

but i couldn't smell it, i could just smell the pussy juice coming off the girls.

woow there

hannibal lecter - some things are best kept to yourself


So, are you a first year Biochemistry

student or a post doc, or what??

I have degrees in engineering, (chemical & mechanical), but right now I'm

pursuing a degree in pharmacology, and am taking biochemistry II with honors. My GPA is 3.8 so far.

[maxo-texas]

So are these living or

cadaver VNO's?

[Archetypical Hybrid (HEC)]

This one goes

out to Bronzi, re: the VNO is a non-functioning organ

The subject invention concerns the

non-systemic administration to the vomeronasal organ (VNO) of certain steroids to alleviate symptoms of PMS and

anxiety, as well as for treatment of elevated body temperature and paroxistic tachycardia (high pulse rate).

Administration provides for contacting neurochemical receptors in the VNO (also known as "Jacobson's organ"), with

one or more steroid(s) or with compositions containing the steroid(s). This organ is accessed through the nostrils

of most higher animals--from snakes to humans, and has been associated, inter alia, with pheromone reception in

certain species (see generally Muller-Schwarze & Silverstein, Chemical Signals, Plenum Press, New York (1980)). The

axons of the neuroepithelia of the vomeronasal organ, located supra palatinal, form the vomeronasal nerve and have

direct synaptic connection to the accessory olfactory bulb and indirect input from there to the cortico-medial

amygdaloid basal forebrain and hypothalamic nuclei of the brain. The distal axons of terminalis nerve neurons may

also serve as neurochemical receptors in the VNO. Stensaas, L. J., et al., J. Steroid Biochem. and Molec. Biol.

(1991) 39:553. This nerve has direct synaptic connection with the hypothalamus.

Results which suggest that the

VNO is a functional chemosensory receptor are reported by Stensaas, L., et al., supra; and by Moran, D. T., et al.,

Garcia-Velasco, J. and M. Mondragon; Monti-Bloch, L. and B. Grosser all in J. Steroid Biochem. and Molec. Biol.

(1991) 39.

[Gegogi]

truthfully, I'm not sure

if the guys could just not smell the -stanone but i couldn't smell it, i could just smell the pussy juice coming

off the girls.

Sheesh, those ladies must have needed a shower and badly! I've got an unusually

senstive nose and I can't smell pussy from a few feet out unless it's really funky. Most women I've been

with--Asians--have only a mild smell if they're excited but clean, and I have to nearly get my nose in it to tell.

The only room filling funk I've experienced came from a woman with a bad bacteria infection. You wanta stay away

from that shit...

As for the VNO, there is much more recent collaborated research than 1991 that indicates

the human VNO is archaic and nonfunctional. Pheromones are intercepted by humans via the sense of smell. This has

been an oft discussed topic on this forum for years. You might wanta search posts my JVK/VNO or read JVK's book for

details on more up-to-date findings.

[Nick666]

Andras, what androstanone are

you talking about? The one in ? How did you get it?

[Andras]

I can't smell none so much, so

what does stanone smell like other than flowery but pungent, i don't ever smell something that pertains to cat

urine or BO.. it's like a weird locker room sweet flower smell kinda thing going, ...I smell it on myself sometimes

so whatever.

[Icehawk]

Andras, what

androstanone are you talking about? The one in ? How did you get

it?

http://www.love-scent.com/product_in.../> <br /> 02

[Shenandoah]

Okay, after reading this

thread, what I was smelling in AQ may have been aNone instead of eNone. Either way I like what I'm smelling.



HEC, thanks for the graph.

How am I going to have time to experiment with Androstendienone as well as AQ

before Thanksgiving?

[MOBLEYC57]

Anybody been

playing around with the androstanone in their chem sets? I have a really big feeling that it acts just like -none

but much more potent. I've worn just -none before but i never had seen other people respond to the smallest amount

of androstanone before. It's potent enough to interfere with even simple tasks, real mindfuck. gonna end up going

right back to just -nol and -rone, all the -nones are just way to powerful for me.

How much have you

been wearing, Andras?

[Andras]

The Androstanone I'm using is

part of the lucky 7 chem set (fun to play with might I add). I've only used like... .25mg in a 4ml solution. maybe

it's been way overkill, but i figured it was nothing even close to the potency of PI/m ( which i have just can't

use since the tiniest amount gives me mad od reactions ). like i said, I dropped like .5ml just on my couch in my

room and my brothers girlfriend noticed on the other side of the basement. It was an awful experience. took me like

a bottle of frebreeze to take it all out.

[Andras]

so ok... i put the smallest

amount of androstanone in my favorite mix, and it worked out quite well. There's one side effect, you're kinda the

boss from there on out.

[Andras]

˚[/SIZE]C,

whereas androstenone's MP is 145˚C (according to the Sigma-Aldrich catalog). Thus, the vapor

pressure is higher and hence it evaporates into the air (where pheromones are active) much moreso than

androstenone.

I think you mean... basically, it's going to shoot out of you a lot faster and

hence more direct/radialogically (aura). very good P.S. since the reactions are making sense to the point.

[gecko]

if you ever feel like giving PI/m

a try again, you can cut it w/something like jojoba oil. i cut mine at a 1:1 ratio w/jojoba oil b/c of the same

reason.

i usually apply just 2 dabs of the mix, but lately have gone up to a drop.

[Archetypical Hybrid (HEC)]

I think

you mean... basically, it's going to shoot out of you a lot faster and hence more direct/radialogically

(aura).

uhh.. Close.. I think What that means in english is that it evaporates faster, and has

a stronger but shorter effect then androstenone just based on the fact that it's more volatile. Also, the molecule

itself is more active directly at the VNO..

P.S. 1mv is nothing to jump up and down and/or run in circles

about..

[Bubba]

P.S. There is also the fact that androstAnone is far more volatile than androstenone. AndrostAnone's MP is

103žC, whereas androstenone's MP is 145žC (according to the Sigma-Aldrich catalog).

Thus, the vapor pressure is higher and hence it evaporates into the air (where pheromones are active) much moreso

than androstenone.

I can't find it in the catalog under either 5-ALPHA-ANDROSTAN-3-ONE or

androstanone. What is the catalog number?

[Archetypical Hybrid (HEC)]

It was an old

catalog - Sigma has discontinued androstanone. There are currently only two suppliers worldwide for the

raw-material.

[jvkohl]

AndrostAnone was hypothesized to be more biologically active at the human female VNO versus androstenone, due

to structure activity relationship observations.

"...there is now overwhelming evidence that the

vomeronasal organ (VNO) is not functional in human adults (Wysocki and Preti 2004)."
Quoted from: Penn, D. (2006)

Chemical Communication.

JVK

[Archetypical Hybrid (HEC)]

You're wrong

JVK, and so are Wysocki and Preti

[Icehawk]

Jezz, can you guys keep the

battle of the DJs in one thread, not jump like pirates from thread to thread?