Kaminski
RM, Marini H, Won-Joo K, and Rogawski MA (2005) Anticonvulsant activity of androsterone and etiocholanolone.
Epilepsia 46:819–827.
"Androstanediol is a positive modulator of
GABAA receptors (Frye et al., 1996) with
potent anxiolytic
and anticonvulsant activity (Frye and Reed, 1998; Reddy,
2004a,b); recently, we confirmed
that androsterone has similar
systemic activities (Kaminski et al., 2005)."
An anxiolytic is any drug or
therapy used in the treatment of anxiety disorders. I am following up on this recent report to determine whether
GABA interaction might be the means by which androsterone (as used in SoE for men) might indicate reduced anxiety in
the wearer as well as reduce anxiety in people (especially women) who are exposed to it.
It's somewhat
satisfying to see the Forum members indicate this effect, but more satisfying to find scientific support for the
effect.
JVK
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