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  1. #1
    Journeyman Sesshoumaru's Avatar
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    Post Prenenologne, "The mother" of all pheromone metabolites

    visit-red-300x50PNG
    In previous reports we described the early time sequence in in vitro [4-14C]

    pregnenolone metabolism in human and rat testicular homogenates and, apart from a difference in the preferred route

    of the conversion of pregnenolone to testosterone, we demonstrated the presence of delta 16-synthetase activity in

    human but not in rat testes. "In the study of testicular function higher monkeys are increasingly used as

    a model for human reproduction. The availability of testes from 2 different species of macaques (rhesus and crab

    eating monkeys) enabled us to compare the in vitro metabolism of pregnenolone in these testes with human testes. The

    pattern obtained in both monkey species were very similar, but completely different from those found in man. The

    delta 4 pathway was the preferred route for the conversion of pregnenolone to testosterone in the monkeys tested,

    the delta 5 pathway in the humans. delta 16-Synthetase activity, a prerequisite for the synthesis of the sex

    pheromone precursors 5,16-androstadien-3 beta-ol and 4,16-androstadien-3-one, was clearly measurable in the human

    but not in the monkey testicular homogenates. So far, man and boar are the only species harbouring delta

    16-synthetase activity in their testes. These in vitro data indicate that the nonhuman primates studied are not

    suitable models for the study of human testicular

    function."

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uid

    s=1688354




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    color]
    "The biosynthesis of testosterone and 4-androstene-3,17-dione and some

    16-androstenes has been studied in homogenates or subcellular fractions of testes from 3-week-old Landrace

    piglets.
    Pregnenolone was converted into 5,16-androstadien-3 beta-ol

    (Androstadienol), 4,16-androstadien-3-one (Androstadienone), 5

    alpha-androst-16-en-3-one (Androstenone) and 5 alpha-androst-16-en-3 alpha- and 3 beta-ols

    (Androstenol, Beta-Androstenol ect..), but the quantities were some 50 times

    less than those formed in the mature boar testis.
    Androgens were also formed in the microsomal fractions but

    the quantities of 4-androstene-3,17-dione (4-Androstenedione) (from side-chain cleavage of

    17-hydroxyprogesterone) and of testosterone (from reduction of 4-androstene-3,17-dione) were 50-70

    times lower than in the adult animal. The kinetic parameters and cofactor preference of the 3 alpha- and 3

    beta-hydroxysteroid dehydrogenases were determined in the cytosolic, microsomal and mitochondrial fractions of

    neonatal porcine
    testes"



    --------------------------------------------------------------------------
    Though the above is just

    saying that Pigs (boars) produce 50-70 times more 16-androstene metabolites (Pheromones, thats probably were all

    that stuff saying pheromone products contain only Pig pheromones came from..)




    But it clearly states that Pregnenolone is the Precursor to Androstadienol,

    Androstadienone, Androstenone, Androstenol, Beta-Androstenol and 4-Androstenedione. DHEA and Testosterone are also

    converted to various 16-androstene metabolites (Pheromones).




    http:/

    /www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=3857187




    --------------------------------------------------------------------------

    Increasing your DHEA, Testosterone

    and Pregnenolone levels will increase your pheromone output substantially (Pregnenolone taking the biggest part of

    this process since it is the actual Precusor of Testosterone and DHEA in the first place).



    http://www.mercola.com/2000/aug/27/adrenals.htm
    [col

    or=red]

  2. #2
    Bodhi Satva CptKipling's Avatar
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    ...and cholesterol is a

    precurser to "prenenologne" ( ), or did I miss a step out?

  3. #3
    Doctor of Scentology DrSmellThis's Avatar
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    DHEA is a precursor to most

    all of the mones, too. Preg creates too many feminine hormones for my taste, in terms of supplementation. DHEA is

    more likely to go to testosterone and the 16-androstenes than preg. Still, it might be good for many in small

    amounts, like 5 mg or something.
    DrSmellThis (creator of P H E R O S)

  4. #4
    Relaxed seduceme's Avatar
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    "Pregnenolone is synthesized

    from cholesterol. This conversion involves hydroxylation at the side chain at C20 and C22 positions, with cleavage

    of the side chain. The enzyme performing this task is cytochrome 450scc, located in the mitochondria, and

    controlled by pituitary tropic hormones, such as ACTH, FSH, LH."

    You could increase preg by increasing

    above highlighted hormones by taking SERMS a.k.a anti-estrogens such as nolvadex or clomid, if its legal in your

    country that is.

    So is prenenologne is the actual precursor of pheromones? Testosterone is never converted

    to pheromones? What about progesterone?

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