Androstenol

[jvkohl]

The Pheromone Androstenol

(5-androst-16-en-3-ol) Is A Neurosteroid Positive Modulator of GABAA Receptor



http://jpet.aspetjournals.org/cgi/c

ontent/abstract/jpet.105.098319v1?ct

From my 1996 article....noradrenergic, dopaminergic, serotoninergic,

and opiotergic pathways; inhibitory neurotransmitters (e.g., gammaaminobutyric acid) and excitatory amino acids

(e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and

corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species specific

influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical

signal GnRH (Grumbach & Styne, 1992).

Technical, of course, but what all this means is that we're now closer

to determinining how pheromones elicit changes in behavior --like those changes elicited by psychotropic drugs that

influence the pathways mentioned above.

JVK

Discussion on this topic can be found by

clicking here.