Icehawk, I think it is the
vomeropherin
pregna-4,20-diene-3,6-dione as per the following study...
Visionary
J Steroid Biochem
Mol Biol. 1998 Apr;65(1-6):237-42.
Modulation of serum testosterone and autonomic function through stimulation
of the male human vomeronasal organ (VNO) with pregna-4,20-diene-3,6-dione.
Monti-Bloch L, Diaz-Sanchez V,
Jennings-White C, Berliner DL.
Department of Psychiatry, University of Utah, Salt Lake City 84108, USA.
In
mammals, external chemosensory signals from conspecifics of the opposite sex acting on vomeronasal organ receptors
can modulate the release of gonadotropins. There is developmental, anatomical and functional evidence showing that
the human vomeronasal organ (VNO) has the characteristics of a chemosensory organ. We have been using naturally
occurring human pheromones to serve as models for designing novel synthetic compounds that we call vomeropherins.
In previous publications we reported that vomeropherin pregna-4,20-diene-3,6-dione (PDD) delivered to the VNO of
normal female and male human volunteers significantly affected male subjects only, decreasing respiration and
cardiac frequency, augmenting alpha brain waves, and significantly decreasing serum luteinizing hormone (LH) and
follicle stimulating hormone (FSH). Results of the present work confirm that PDD produces a local dose-dependent
effect in the male human VNO. This is followed by a mild parasympathomimetic effect characterized by 10% increase of
vagal tone, together with decreased frequency of electrodermal activity events. Furthermore, PDD locally delivered
to the male human VNO significantly decreases serum LH and testosterone (p < 0.01). The present results
contribute additional evidence supporting the functionality of the human VNO and its repercussions in autonomic and
psychophysiological functions, as well as in neuroendocrine secretions.
PMID: 9699878 [PubMed - indexed for
MEDLINE]
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