jvkohl
01-13-2006, 06:59 PM
The Pheromone Androstenol
(5-androst-16-en-3-ol) Is A Neurosteroid Positive Modulator of GABAA Receptor
http://jpet.aspetjournals.org/cgi/c
ontent/abstract/jpet.105.098319v1?ct (http://jpet.aspetjournals.org/cgi/content/abstract/jpet.105.098319v1?ct)
From my 1996 article....noradrenergic, dopaminergic, serotoninergic,
and opiotergic pathways; inhibitory neurotransmitters (e.g., gammaaminobutyric acid) and excitatory amino acids
(e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and
corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species specific
influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical
signal GnRH (Grumbach & Styne, 1992).
Technical, of course, but what all this means is that we're now closer
to determinining how pheromones elicit changes in behavior --like those changes elicited by psychotropic drugs that
influence the pathways mentioned above.
JVK
Discussion on this topic can be found by
clicking here. (http://www.pherolibrary.com/forum/showthread.php?t=15353)
(5-androst-16-en-3-ol) Is A Neurosteroid Positive Modulator of GABAA Receptor
http://jpet.aspetjournals.org/cgi/c
ontent/abstract/jpet.105.098319v1?ct (http://jpet.aspetjournals.org/cgi/content/abstract/jpet.105.098319v1?ct)
From my 1996 article....noradrenergic, dopaminergic, serotoninergic,
and opiotergic pathways; inhibitory neurotransmitters (e.g., gammaaminobutyric acid) and excitatory amino acids
(e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and
corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species specific
influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical
signal GnRH (Grumbach & Styne, 1992).
Technical, of course, but what all this means is that we're now closer
to determinining how pheromones elicit changes in behavior --like those changes elicited by psychotropic drugs that
influence the pathways mentioned above.
JVK
Discussion on this topic can be found by
clicking here. (http://www.pherolibrary.com/forum/showthread.php?t=15353)