**DONOTDELETE**
12-01-2001, 01:50 AM
How many of you have read the full text of the Realm patent on the use of androstadienone in fragrances? You can read the patent at the following link:
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/srchnum.htm&r=1&f=G&l=50&s1=\'5278141\'.WKU.&OS=PN/5278141&RS=PN/5278141 (\"http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/srchnum.htm&r=1&f=G&l=50&s1=\'5278141\'.WKU.&OS=PN/5278141&RS=PN/5278141\")
Here\'s an interesting excerpt about the concentration of pheromones used, even though the exact ratio is a secret:
As a concentrate, pheromones may or may not have a detectable odor. Since they bind to receptors which are physically and functionally distinct from
olfactory receptors, they may or may not carry their own smell. However, some of the pheromones described herein do in fact have an odor. As a
concentrate, the odor of these pheromones may not necessarily be pleasant. Thus, when diluted in a perfume the practical upper concentration limit is
determined by the pleasantness of the resulting fragrance. Generally, human pheromones are present in the fragrance composition of the subject invention
at a concentration of no more than about 200 .mu.g/ml, more commonly no more than about 100 .mu.g/ml, preferably no more than about 50 .mu.g/ml,
and more preferably no more than about 25 .mu.g/ml.
Pheromones have a very low threshold of detectable receptor binding and they are effective at low concentrations. Generally, human pheromones are
present in the fragrance composition of the subject invention at a concentration of at least about 50 ng/ml, more commonly at least about 100 ng/ml,
preferably at least about 500 ng/ml, more preferably at least about 1 .mu.g/ml.
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/srchnum.htm&r=1&f=G&l=50&s1=\'5278141\'.WKU.&OS=PN/5278141&RS=PN/5278141 (\"http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/srchnum.htm&r=1&f=G&l=50&s1=\'5278141\'.WKU.&OS=PN/5278141&RS=PN/5278141\")
Here\'s an interesting excerpt about the concentration of pheromones used, even though the exact ratio is a secret:
As a concentrate, pheromones may or may not have a detectable odor. Since they bind to receptors which are physically and functionally distinct from
olfactory receptors, they may or may not carry their own smell. However, some of the pheromones described herein do in fact have an odor. As a
concentrate, the odor of these pheromones may not necessarily be pleasant. Thus, when diluted in a perfume the practical upper concentration limit is
determined by the pleasantness of the resulting fragrance. Generally, human pheromones are present in the fragrance composition of the subject invention
at a concentration of no more than about 200 .mu.g/ml, more commonly no more than about 100 .mu.g/ml, preferably no more than about 50 .mu.g/ml,
and more preferably no more than about 25 .mu.g/ml.
Pheromones have a very low threshold of detectable receptor binding and they are effective at low concentrations. Generally, human pheromones are
present in the fragrance composition of the subject invention at a concentration of at least about 50 ng/ml, more commonly at least about 100 ng/ml,
preferably at least about 500 ng/ml, more preferably at least about 1 .mu.g/ml.