Sandalwood and Pheromones

[bjf]

http://www.leffingwell.com/chirality/steroid_&_sandalwood.htm

There's a odorless -none (-).

[metropolitan]

would love to read this

article but the html page is no longer active. did anyone by any chance download it or copy it?

thanks

[NaughtieGirl]

would

love to read this article but the html page is no longer active. did anyone by any chance download it or copy it?



thanks
Hey Metro!

When I clicked on it, I came up with this (see below) That makes me suspect your

browser is at fault. Which one are you using?
Intriguing link btw, that I will delve into tomorrow.

Thanks!our Perception


http://www.leffingwell.com/chirality/image.gif

Steroid Urine Type Odorants &

Sandalwood Type Odorants

by John C. Leffingwell,

Ph.D.

Photo by permission of M. Roudintska -

Art &

Parfum (http://www.art-et-parfum.com/)

Cyclic

Terpenoid Odorants (http://www.leffingwell.com/chirality/cyclic_terpenoid.htm)

Bicyclic Terpenoid

Odorants (http://www.leffingwell.com/chirality/bicyclic_terpenoid.htm)

Acyclic

Terpenoid

Odorants (http://www.leffingwell.com/chirality/acyclic_terpenoid.htm)

Ionones,

Irones, Damascones & Structurally Related

Odorants (http://www.leffingwell.com/chirality/ionone_irone.htm)

Acyclics

(Alcohols, Esters, Acids,

Aldehydes) (http://www.leffingwell.com/chirality/acyclics.htm)

Lactones

(http://www.leffingwell.com/chirality/lactones.htm)

Sesquiterpenoi

d Related

Odorants (http://www.leffingwell.com/chirality/sesquiterpenoid_%26_diterpen.htm)

Steroi

d Urine Type Odorants (http://www.leffingwell.com/chirality/steroid_&_sandalwood.htm)

Sandalwood Type

Odorants (http://www.leffingwell.com/chirality/steroid_&_sandalwood.htm)

Musk

Odorants (http://www.leffingwell.com/chirality/musk.htm)

Miscellaneous

(http://www.leffingwell.com/chirality/miscellaneous.htm)

Enantiomer & Odor Description Odour Threshold

(PPB)

Steroid Type

Odorants

.

(+)-androstenone

- strong urine

odor (http://www.leffingwell.com/chirality/androstenone.htm)

0.18

(-)-andros

tenone -

odorless (http://www.leffingwell.com/chirality/androstenone.htm)

Odorless

(-)-androsta-4,16-dien-3-one -

odorless (http://www.leffingwell.com/chirality/androstadienone.htm)

Odorless

(+)-androsta-4,16-dien-3-one - very persistent odor of urine &

sweat (http://www.leffingwell.com/chirality/androstadienone.htm)

0.98

(+)-5-alph

a-androst-16-en-3-alpha-ol (http://www.leffingwell.com/chirality/androstenol.htm) - Animalic, musk-like odor with a strong (fine) sandalwood

tonality

0.02

ent-(-)-5-alpha-andro

st-16-en-3-alpha-ol (http://www.leffingwell.com/chirality/androstenol.htm) - Weaker with a detection threshold level about six orders of magnitude higher

than 5-alpha-androst-16-en-3-alpha-ol

NA

Nature Identical Sandalwood

Odorants



(-)-(1'S,2'R,4'R)-

(Z)-beta-santalol (http://www.leffingwell.com/chirality/santalol.htm)- Typical sandalwood scent, identical to the natural

product.

NA

(+)-(1'R,2'S,4'S)-(Z)-b

eta-santalol (http://www.leffingwell.com/chirality/santalol.htm) - No scent

(odorless).

Odorless

(-)-(1'S,2'R,4R)- (E)-beta-santalol (http://www.leffingwell.com/chirality/santalol.htm) - Scent similar to (-)-(1'S,2'R,4'R)-(Z)-beta-santalol but less

intense.

NA

(+)-(1'R,2'S,4'S)-

(E)-beta-santalol (http://www.leffingwell.com/chirality/santalol.htm) - No scent (odorless).

Odorless

Sandalwood Type Odorants from

Campholenic aldehyde





(-)-(1'R)-4-(2',2',3'-trimethyl-

3'-cyclopenten-1'-yl)-4-penten-1-al - fragrance further possessing an aldehydic note,

reminiscent of citronellal, citrusy, spicy, recalling the odor of the citronella leaves. As to its bottom note, it

has a character which is reminiscent of the odor of 3-(4-tert-butyl-1-phenyl)-2-methylpropanal, but with an even

greener connotation and a slightly orangy

aspect (http://www.leffingwell.com/chirality/sandalwood_5.htm)

NA

(+)-(1'S)

-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl)-4-penten-1-al - a more metallic and

aldehydic odor, recalling that of trans-4-decenal, and the bottom note of which is more floral and even stronger in

the aqueous character. The use of this latter compound to enhance the latter odor character in perfumed compositions

and articles is in fact preferred to that of its

(-)-(1'R)-enantiomer (http://www.leffingwell.com/chirality/sandalwood_5.htm)

NA

(-)-(1'R)-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl)-4-pentenenitrile -

a woody-citrus, fruity and slightly fatty odor prefered to the

(+)-(1'S)-isomer (http://www.leffingwell.com/chirality/sandalwood_7.htm)

NA

(+)-(1'S)-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl)-4-pentenenitrile - not

as prefered an odor as the

(-)-(1'R)-isomer (http://www.leffingwell.com/chirality/sandalwood_7.htm)

NA

(-)-(1'R,2R)-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl) -4-pentenenitrile -

citrus, fruity and fresh character accompanied by a sandalwood bottom

character (http://www.leffingwell.com/chirality/sandalwood_7.htm)

NA

(+)-(1S,2s)-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl) -4-pentenenitrile - odor not

described other than to say the (1'R)-isomers are

preferred (http://www.leffingwell.com/chirality/sandalwood_7.htm)

(-)-(1'R,2S)

-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl) -4-pentenenitrile - a sandalwood

odor wherein the desired fruity-citrus character of the (-)-(1'R,2R)-isomer is no longer

present (http://www.leffingwell.com/chirality/sandalwood_7.htm)

NA

(+)-(1'S

,2R)-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl) -4-pentenenitrile - odor not

described other than to say the (1'R)-isomers are

preferred (http://www.leffingwell.com/chirality/sandalwood_7.htm)

(-)-(1'R,2R)

-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl) -4-penten-1-ol - elegant and powerful sandalwood note

(prefered of the four

isomers) (http://www.leffingwell.com/chirality/sandalwood_6.htm)

NA

(+)-(1'

S,2S)-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl) -4-penten-1-ol - odor is less

rich in the precious "lait de santal" type odor character present in the (-)-(1'R,2R)- and (-)-(1'R,2S)-

isomers (http://www.leffingwell.com/chirality/sandalwood_6.htm)

NA

(-)-(1'R

,2S)-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl) -4-penten-1-ol - sandalwood

note is not as powerful as the (-)-(1'R,2R)-isomer but is accompanied of a more marked woody-cedar

character (http://www.leffingwell.com/chirality/sandalwood_6.htm)

NA

(+)-(1S,2R)-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl) -4-penten-1-ol - odor is

less rich in the precious "lait de santal" type odor character present in the (-)-(1'R,2R)- and (-)-(1'R,2S)-

isomers (http://www.leffingwell.com/chirality/sandalwood_6.htm)

NA

(-)-(1'R

,E)-3,3-dimethyl-5-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl)-4-penten-2-ol - develops a

sandalwood note, the character of which is strongly reminiscent of the typical milky odor of

sandalwood (http://www.leffingwell.com/chirality/sandalwood_1.htm)

NA

(+)-(1

'S,E)-3,3-dimethyl-5-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl)-4-penten-2-ol - drier,

more woody-cedar and less milky than that of its (-)-(1'R,E)-

isomer (http://www.leffingwell.com/chirality/sandalwood_1.htm)

NA

(+)-(1'S,

2S,E)-3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol - develops a

sandalwood note of remarkable strength, wherein the typical milky character is represented at its best and

accompanied by a slightly animal note; prefered of four possible

isomers (http://www.leffingwell.com/chirality/sandalwood_1.htm)

NA

(-)-(1'R

,2R,E)-3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol - weakest and less

characteristic sandalwood note than any of the other

isomers (http://www.leffingwell.com/chirality/sandalwood_1.htm)

NA

(+)-(1'S

,2R,E)-3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol - ranked in 3d place

of 4 isomers for its sandalwood

odor (http://www.leffingwell.com/chirality/sandalwood_1.htm)

NA

(-)-(1'R,2S

,E)-3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol - weaker and less

characteristic sandalwood note than the (+)-(1'S,2S,E)-isomer but superior to the (+)-(1'S,2R,E)- or

(-)-(1'R,2R,E)-

isomers (http://www.leffingwell.com/chirality/sandalwood_1.htm)

NA

(1'R,E)-

(+)-2-Methyl-4-(2',2',3'-trimethyl-cyclopent-3-enyl)-but-2-en-1-ol - fresh and strong

sandalwood oil odor associated with green

trees (http://www.leffingwell.com/chirality/sandalwood_3.htm)

51

(1'S,E)-(-

)-2-Methyl-4-(2',2',3'-trimethyl-cyclopent-3-enyl)-but-2-en-1-ol - dry and weak sandalwood

oil odor with a milky and floral

note (http://www.leffingwell.com/chirality/sandalwood_3.htm)

424

(1'R,E)-(-

)-2-Ethyl-4-(2',2',3'-trimethyl-cyclopent-3-enyl)-but-2-en-1-ol - clean, bright and strong

sandalwood oil odor with richness and a woody

note (http://www.leffingwell.com/chirality/sandalwood_2.htm)

0.85

(1'S,E)-(

-)-2-Ethyl-4-(2,2,3-trimethyl-cyclopent-3-enyl)-but-2-en-1-ol - milky sandalwood oil odor

with a cedar

character (http://www.leffingwell.com/chirality/sandalwood_2.htm)

44

(-)-(1R)-2-methyl-4-(2',2',3'- trimethyl-3'-cyclopenten-1'-yl) -4-penten-1-al - possesses an

unexpected odor in view of the prior knowledge regarding the odor properties of campholenic aldehyde derivatives. It

develops a woody-sandalwood type odor note, slightly aldehydic, which is more reminiscent of the cedar-pine odor

connotation than of the sandalwood type one, which note is combined with a distinct marine, ozone character. The

latter is reinforced in the bottom note, which is strongly ozone-marine-like, recalling the odor of seaweeds. In

addition, the odor of this compound has a good strength and

tenacity. (http://www.leffingwell.com/chirality/sandalwood_4.htm)

NA

(+)-(1S)-2-methyl-4-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl) -4-penten-1-al - woody,

sandalwood, aldehydic, faintly

aqueous (http://www.leffingwell.com/chirality/sandalwood_4.htm)

NA



(1'S,1''S,2'S,3''R,5''R)-Javanol - sandalwood, creamy, warm,

strong (http://www.leffingwell.com/chirality/javanol.htm)

NA

(1'R,1''R,2R,3''S,5''S)-Javanol - lactonic, lily of the

valley (http://www.leffingwell.com/chirality/javanol.htm)

NA

(1'R,1''S,2R,3''R,5''R)-Javanol - lactonic, with a sandalwood

aspect (http://www.leffingwell.com/chirality/javanol.htm)

NA

(1'S,1''R,2S,3''S,5''S)-Javanol - floral, rosy, milky,

sandalwood (http://www.leffingwell.com/chirality/javanol.htm)

NA

(-)-(1

S,E)-5-(2',2-dimethyl-3'-methylene-1'-cyclohexyl)-3,3-dimethyl-4-penten-2-ol (http://www.leffingwell.com/chirality/sandalwood_8.htm) - Woody, sandal, sweet

note, reminiscent of the odor of the bark and milk of the sandalwood

tree.

NA

(+)-(1'R,E)-5-(2',2-dim

ethyl-3'-methylene-1'-cyclohexyl)-3,3-dimethyl-4-penten-2-ol (http://www.leffingwell.com/chirality/sandalwood_8.htm)- Sandalwood odor, but distinctly

different than the (-)-(1S,E)-isomers

NA





Other Sandalwood

Odorants



(1R,3R

,1'S,2'R,4'S,6'S)-(+)-threo-trans-3-isocamphylcyclohexanol (http://www.leffingwell.com/chirality/isocamphylcyclohexanols.htm) - Strong, diffusive, and

sandalwood-like odor; natural sandalwood odor, but very strong and

keen

0.2

(1S,3S,1'R,2S,4'R,6'R)-(-)-threo-trans-3-isocamphylcyclohexanol (http://www.leffingwell.com/chirality/isocamphylcyclohexanols.htm) - weak, moldy and woody

odor

200

(1S,3S,1'S,2R,4'S,6'S) (+)-erythro-trans-3-isocamphylcyclohexanol (http://www.leffingwell.com/chirality/isocamphylcyclohexanols.htm) - sandalwood like odor without moldy feeling,

and it is sufficiently

diffusive

7

(1R,3R,1'R

,2'S,4'R,6'R)-(-)-erythro-trans-3-isocamphylcyclohexanol (http://www.leffingwell.com/chirality/isocamphylcyclohexanols.htm) - strong, warm sandalwood

odor

3

(+)-(1S,3R,6

R,8R)-8-tertbutylbicyclo[4.4.0]decan-3-ol (http://www.leffingwell.com/chirality/tertbutylbicyclodecan-3-ols.htm) - strong, sandalwood like, warm, sweet and fatty, long

persisting,

NA

(-)-

(1R,3S,6S,8S)-8-tertbutylbicyclo[4.4.0]decan-3-ol (http://www.leffingwell.com/chirality/tertbutylbicyclodecan-3-ols.htm) - very weak, fatty, hardly perceptible, remote

reminiscent to animal

notes.

NA

(2S,3R,4E)-3-m

ethyl-4-[(1R,2R,6R,7R)-tricyclo[5.2.1.02,6]dec-4-en-8-ylidene]butan-2-ol (http://www.leffingwell.com/chirality/tricyclodecenylbutanol.htm)- very strong, sandal(wood),

animalic

5

(2R,3S,4E)-3-

methyl-4-[(1S,2S,6S,7S)-tricyclo[5.2.1.02,6]dec-4-en-8-ylidene]butan-2-ol (http://www.leffingwell.com/chirality/tricyclodecenylbutanol.htm)- weak,

woody

168

(2R,3S,4E)-3-m

ethyl-4-[(1R,2R,6R,7R)-tricyclo[5.2.1.02,6]dec-4-en-8-ylidene]butan-2-ol (http://www.leffingwell.com/chirality/tricyclodecenylbutanol.htm) - sandal(wood),

animalic

70

(2S,3R,4E)-3

-methyl-4-[(1S,2S,6S,7S)-tricyclo[5.2.1.02,6]dec-4-en-8-ylidene]butan-2-ol (http://www.leffingwell.com/chirality/tricyclodecenylbutanol.htm) -

woody

72

(2R,3R,4E)-3-me

thyl-4-[(1R,2R,6R,7R)-tricyclo[5.2.1.02,6]dec-4-en-8-ylidene]butan-2-ol (http://www.leffingwell.com/chirality/tricyclodecenylbutanol.htm) - sandal(wood),

floral

137

(2S,3S,4E)-3-

methyl-4-[(1S,2S,6S,7S)-tricyclo[5.2.1.02,6]dec-4-en-8-ylidene]butan-2-ol (http://www.leffingwell.com/chirality/tricyclodecenylbutanol.htm)- very weak

floral

159

(2S,3S,4E)-3-

methyl-4-[(1R,2R,6R,7R)-tricyclo[5.2.1.02,6]dec-4-en-8-ylidene]butan-2-ol (http://www.leffingwell.com/chirality/tricyclodecenylbutanol.htm)- strong sandal(wood),

floral

46

(2R,3R,4E)-3-m

ethyl-4-[(1S,2S,6S,7S)-tricyclo[5.2.1.02,6]dec-4-en-8-ylidene]butan-2-ol (http://www.leffingwell.com/chirality/tricyclodecenylbutanol.htm) - weak

floral

204

(1R,2'R,3'S)-Ebanol

(http://www.leffingwell.com/chirality/ebanol.htm) - weak, no sandalwood odor relevance

>100 (relative in

series)

(1S,2'S,3'R)-Ebanol (http://www.leffingwell.com/chirality/ebanol.htm)

- Powerful sandalwood, more than 100X more powerful than its enantiomer (based on relative GC sniff threshold) and

more than 3X stronger than (1R,2'S,3'R)-Ebanol

1 (relative in

series)

(1R,2'S,3'S)-Ebanol (http://www.leffingwell.com/chirality/ebanol.htm)

- Slight sandalwood relevance, both enantiomers weak

>100 (relative in

series)

(1S,2'R,3'R)-Ebanol (http://www.leffingwell.com/chirality/ebanol.htm)

- No sandalwood relevance, both enantiomers weak

>100 (relative in

series)

(1R,2'S,3'R)-Ebanol (http://www.leffingwell.com/chirality/ebanol.htm)

- Powerful sandalwood, more than 33X more powerful than its enantiomer and more than 3X weaker than

(1S,2'S,3'R)-Ebanol

3 (relative in

series)

(1S,2'R,3'S)-Ebanol (http://www.leffingwell.com/chirality/ebanol.htm)

- no sandalwood relevance

>100 (relative in

series)

(1R,2'R,3'R)-Ebanol (http://www.leffingwell.com/chirality/ebanol.htm)

- no sandalwood relevance

>100 (relative in

series)

(1S,2'S,3'S)-Ebanol (http://www.leffingwell.com/chirality/ebanol.htm)

- no sandalwood relevance

>100 (relative in

series)

HOME (http://www.leffingwell.com/index.htm)

Copyright 2002 - Leffingwell & Associates

[metropolitan]

when i try the link now it

works, so maybe the site was down.
thanks for posting the info. been playing with essential oils and fragrance

oils and sandalwood is a great one.
i recommend checking out the body shop perfume oils.

[NaughtieGirl]

when i

try the link now it works, so maybe the site was down.
thanks for posting the info. been playing with essential

oils and fragrance oils and sandalwood is a great one.
i recommend checking out the body shop perfume oils.


I agree, essential oils and aromatherapy seem to be the perfect complement to pheromones. Some of the nicer EO's

are quite pricey though. Sandalwood is one of the nice ones I did splurge on. There is tons of good info on this

forum about EO's as well. You can access it with the search function.

[Rbt]

when i try the

link now it works, so maybe the site was down.
thanks for posting the info. been playing with essential oils and

fragrance oils and sandalwood is a great one.
i recommend checking out the body shop perfume oils.


Browsers and the internet itself can get finicky. Often when I get an "unable to find" or other failure, if I come

back a while later all is fine. Although sometimes things *do* seem to screw up the browser software and I find it

best to shut it down and start anew (sometimes just the browser, othertimes I turn off the whole system and reboot.

Only way to totally clear out any junk in the RAM memory.)

[BassMan]

http://www.leffingwell.com/chiralit

y/steroid_&_sandalwood.htm (http://www.leffingwell.com/chirality/steroid_&_sandalwood.htm)

There's a odorless -none (-).
These are what are known as

opto-isomers. Identical except one is a mirror image of the other. There are many such compounds in nature. The ones

with the "wrong" mirror image don't fit into the proper receptor sites in the body and are therefore usually not

biologically active.

In other words, there is an odorless none, but it is not a pheromone.

Bass

[NaughtieGirl]

when i

try the link now it works, so maybe the site was down.
thanks for posting the info. been playing with essential

oils and fragrance oils and sandalwood is a great one.
i recommend checking out the body shop perfume oils.


Me too! If you're new at it I can recommend Mindy Green's "Natural Perfumes" I just bought it from Amazon.com.

It even has a paragraph or two about pheromones in the introduction.

Contents go a bit like this:
- basics of

aromatherapy
- blending fundamentals,
- a review of 40 oils
- 2 beginning blending lessons
- 30 fragrance

recipes
- elemental blends
- resource directory

What I like about it is that she suggests blends and then

tells you which particular oil to vary in quantity to make it suit your own taste. Proportions for fragrance

products. EO note type and odor intensity.

But I'm really new at it. You might already know all that stuff.



BassMan: Thanks for the info. Learned something new today! I was somewhat mystified by that link.

[DrSmellThis]

These are what

are known as opto-isomers. Identical except one is a mirror image of the other. There are many such compounds in

nature. The ones with the "wrong" mirror image don't fit into the proper receptor sites in the body and are

therefore usually not biologically active.

In other words, there is an odorless none, but it is not a

pheromone.

BassYou mean there's a good chance it's not, don't you? Can we be certain?

[metropolitan]

yeah, i also have the mindy

green book!
another good book is

Per

fumes, Splashes & Colognes : Discovering and Crafting Your Personal Fragrances
by

(http://www.amazon.com/exec/obidos/tg/detail/-/0882669850/002-5361581-5725667?%5Fencoding=UTF8&v=glance)

Nancy M. Booth (http://www.amazon.com/exec/obidos/tg/detail/-/0882669850/002-5361581-5725667?%5Fencoding=UTF8&v=glance)
a lot of informatioin on perfumery, essential oils, categories of scents and a lot more.

worth buying if you're into personal perfumery.

i also recently got

Sce

nts & Scentuality: Essential Oils & Aromatherapy for Romance, Love, and Sex (Paperback)
by

(http://www.amazon.com/exec/obidos/tg/detail/-/1577310756/002-5361581-5725667?%5Fencoding=UTF8&v=glance)

Valerie Ann Worwood (http://www.amazon.com/exec/obidos/tg/detail/-/1577310756/002-5361581-5725667?%5Fencoding=UTF8&v=glance)
and this is an excellent aromatherapy for love, sex and romance. a tons of formulas and

recipes and what the intended results are for. it uses different angle. less concerned with perfumery and more with

the emotional, psychological, and sensual reactions we have to certain essential oils. very very good.

[NaughtieGirl]

yeah, i

also have the mindy green book!
another good book is

Per

fumes, Splashes & Colognes : Discovering and Crafting Your Personal Fragrances
by

(http://www.amazon.com/exec/obidos/tg/detail/-/0882669850/002-5361581-5725667?%5Fencoding=UTF8&v=glance)

Nancy M. Booth (http://www.amazon.com/exec/obidos/tg/detail/-/0882669850/002-5361581-5725667?%5Fencoding=UTF8&v=glance)
a lot of informatioin on perfumery, essential oils, categories of scents and a lot more. worth

buying if you're into personal perfumery.

i also recently got

Sce

nts & Scentuality: Essential Oils & Aromatherapy for Romance, Love, and Sex (Paperback)
by

(http://www.amazon.com/exec/obidos/tg/detail/-/1577310756/002-5361581-5725667?%5Fencoding=UTF8&v=glance)

Valerie Ann Worwood (http://www.amazon.com/exec/obidos/tg/detail/-/1577310756/002-5361581-5725667?%5Fencoding=UTF8&v=glance)
and this is an excellent aromatherapy for love, sex and romance. a tons of formulas and

recipes and what the intended results are for. it uses different angle. less concerned with perfumery and more with

the emotional, psychological, and sensual reactions we have to certain essential oils. very very good.
Hey

thanks! :thumbsup: I already bought Nancy Booth's book along with Mindy Green's but I haven't read it yet. I

spent the evening last night highlighting in Mindy Green's book. V.A. Worwood's book is definitely next on my

list. I just love the "learning curve" of new endeavors!

[countesszero]

Hi Madini.com is also a

good site if you want EO's or essences. This is were I get my honeysuckle, violet and rose oils from. Their prices

are reasonable too.

The Countess

[metropolitan]

Hi Madini.com is

also a good site if you want EO's or essences.
i checked them out, sounds interesting, so i just ordered

some of their samples.

[BassMan]

You mean

there's a good chance it's not, don't you? Can we be certain?It would probably be better to state it

as:

If the odorless molecule _is_ a pheromone, it's probably a quite different one from the odorous one.



For example, the drug thalidomide - it was prescribed for morning sickness, later found to cause profound birth

defects. One isomer controlled the morning sickness, the other the birth defects.

Another example - vitamin E.

The D form is active in the body, the L form inactive. Which is why synthetic E (which is a mixture of the D and L

forms) is only half as potent as natural E (which is almost all D).

So, yeah, I probably overstated it, but

optical rotation usually makes a very large difference in biological activity.

-Bass

[DrSmellThis]

Thanks for the clarification.

:)

[Le Sillage]

Yeah, D and L phenylalanine have

totally different functions, both generally positive, but very different.

So do R and S ALA. I don't

remember which, but one is negative, one is beneficial. Together, they sort of even out into a zero sum

game.

With something like androstadienone, there's a definite receptor, and we know what it is (the

vno).

With something like androstenol, we see a physiological change in subjects, but have no idea why it's

occuring. It's not through the vno.

That doesn't mean that a chiral switch of pheromones can't be tested,

however. Everyone of us here is testing mones all the time, but there's a catch with chiral forms, and that's that

there's barely ever enough to test...

Chiral switches are hard to get, and most known synthesis routes are

way too costly to be ready for even a smidge of prime time. You suffer from the fact that you don't have the

research dollars in this industry that you do in pharmaceuticals. Even those multibillion dollar companies avoided

chiral switches for years, due to the costs of development.

This article says that it took 15 years

(supposedly) to get Nexium out of Prilosec. Guh! Nexium is one half the man that Prilosec is. Lots of good info

here:

http://pubs.acs.org/cen/coverstory/8118/8118chiral2.html