Sesshoumaru
07-22-2004, 03:31 PM
In previous reports we described the early time sequence in in vitro [4-14C]
pregnenolone metabolism in human and rat testicular homogenates and, apart from a difference in the preferred route
of the conversion of pregnenolone to testosterone, we demonstrated the presence of delta 16-synthetase activity in
human but not in rat testes. "In the study of testicular function higher monkeys are increasingly used as
a model for human reproduction. The availability of testes from 2 different species of macaques (rhesus and crab
eating monkeys) enabled us to compare the in vitro metabolism of pregnenolone in these testes with human testes. The
pattern obtained in both monkey species were very similar, but completely different from those found in man. The
delta 4 pathway was the preferred route for the conversion of pregnenolone to testosterone in the monkeys tested,
the delta 5 pathway in the humans. delta 16-Synthetase activity, a prerequisite for the synthesis of the sex
pheromone precursors 5,16-androstadien-3 beta-ol and 4,16-androstadien-3-one, was clearly measurable in the human
but not in the monkey testicular homogenates. So far, man and boar are the only species harbouring delta
16-synthetase activity in their testes. These in vitro data indicate that the nonhuman primates studied are not
suitable models for the study of human testicular
function."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uid
s=1688354 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abs
tract&list_uids=1688354)
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[/
color]
"The biosynthesis of testosterone and 4-androstene-3,17-dione and some
16-androstenes has been studied in homogenates or subcellular fractions of testes from 3-week-old Landrace
piglets. Pregnenolone was converted into 5,16-androstadien-3 beta-ol
(Androstadienol), 4,16-androstadien-3-one (Androstadienone), 5
alpha-androst-16-en-3-one (Androstenone) and 5 alpha-androst-16-en-3 alpha- and 3 beta-ols
(Androstenol, Beta-Androstenol ect..), but the quantities were some 50 times
less than those formed in the mature boar testis. Androgens were also formed in the microsomal fractions but
the quantities of 4-androstene-3,17-dione (4-Androstenedione) (from side-chain cleavage of
17-hydroxyprogesterone) and of testosterone (from reduction of 4-androstene-3,17-dione) were 50-70
times lower than in the adult animal. The kinetic parameters and cofactor preference of the 3 alpha- and 3
beta-hydroxysteroid dehydrogenases were determined in the cytosolic, microsomal and mitochondrial fractions of
neonatal porcine testes"
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Though the above is just
saying that Pigs (boars) produce 50-70 times more 16-androstene metabolites (Pheromones, thats probably were all
that stuff saying pheromone products contain only Pig pheromones came from..)
But it clearly states that Pregnenolone is the Precursor to Androstadienol,
Androstadienone, Androstenone, Androstenol, Beta-Androstenol and 4-Androstenedione. DHEA and Testosterone are also
converted to various 16-androstene metabolites (Pheromones).
http:/
/www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3857187 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3857187)
--------------------------------------------------------------------------
Increasing your DHEA, Testosterone
and Pregnenolone levels will increase your pheromone output substantially (Pregnenolone taking the biggest part of
this process since it is the actual Precusor of Testosterone and DHEA in the first place).
http://www.mercola.com/2000/aug/27/adrenals.htm
[col
or=red]
pregnenolone metabolism in human and rat testicular homogenates and, apart from a difference in the preferred route
of the conversion of pregnenolone to testosterone, we demonstrated the presence of delta 16-synthetase activity in
human but not in rat testes. "In the study of testicular function higher monkeys are increasingly used as
a model for human reproduction. The availability of testes from 2 different species of macaques (rhesus and crab
eating monkeys) enabled us to compare the in vitro metabolism of pregnenolone in these testes with human testes. The
pattern obtained in both monkey species were very similar, but completely different from those found in man. The
delta 4 pathway was the preferred route for the conversion of pregnenolone to testosterone in the monkeys tested,
the delta 5 pathway in the humans. delta 16-Synthetase activity, a prerequisite for the synthesis of the sex
pheromone precursors 5,16-androstadien-3 beta-ol and 4,16-androstadien-3-one, was clearly measurable in the human
but not in the monkey testicular homogenates. So far, man and boar are the only species harbouring delta
16-synthetase activity in their testes. These in vitro data indicate that the nonhuman primates studied are not
suitable models for the study of human testicular
function."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uid
s=1688354 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abs
tract&list_uids=1688354)
--------------------------------------------------------------------------
[/
color]
"The biosynthesis of testosterone and 4-androstene-3,17-dione and some
16-androstenes has been studied in homogenates or subcellular fractions of testes from 3-week-old Landrace
piglets. Pregnenolone was converted into 5,16-androstadien-3 beta-ol
(Androstadienol), 4,16-androstadien-3-one (Androstadienone), 5
alpha-androst-16-en-3-one (Androstenone) and 5 alpha-androst-16-en-3 alpha- and 3 beta-ols
(Androstenol, Beta-Androstenol ect..), but the quantities were some 50 times
less than those formed in the mature boar testis. Androgens were also formed in the microsomal fractions but
the quantities of 4-androstene-3,17-dione (4-Androstenedione) (from side-chain cleavage of
17-hydroxyprogesterone) and of testosterone (from reduction of 4-androstene-3,17-dione) were 50-70
times lower than in the adult animal. The kinetic parameters and cofactor preference of the 3 alpha- and 3
beta-hydroxysteroid dehydrogenases were determined in the cytosolic, microsomal and mitochondrial fractions of
neonatal porcine testes"
--------------------------------------------------------------------------
Though the above is just
saying that Pigs (boars) produce 50-70 times more 16-androstene metabolites (Pheromones, thats probably were all
that stuff saying pheromone products contain only Pig pheromones came from..)
But it clearly states that Pregnenolone is the Precursor to Androstadienol,
Androstadienone, Androstenone, Androstenol, Beta-Androstenol and 4-Androstenedione. DHEA and Testosterone are also
converted to various 16-androstene metabolites (Pheromones).
http:/
/www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3857187 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3857187)
--------------------------------------------------------------------------
Increasing your DHEA, Testosterone
and Pregnenolone levels will increase your pheromone output substantially (Pregnenolone taking the biggest part of
this process since it is the actual Precusor of Testosterone and DHEA in the first place).
http://www.mercola.com/2000/aug/27/adrenals.htm
[col
or=red]